Speciation of precious metal anti-cancer complexes by NMR spectroscopy
نویسندگان
چکیده
منابع مشابه
Protein complexes studied by NMR spectroscopy.
Recent advances in NMR methods now allow protein complexes to be studied in great detail in a wide range of solution conditions. Isotope-enrichment strategies, resonance-assignment approaches and structural-determination methods have evolved to the point where almost any type of complex involving proteins of reasonable size may be studied in a straightforward way. A variety of isotope editing a...
متن کاملApplications of Paramagnetic NMR Spectroscopy for Monitoring Transition Metal Complex Stoichiometry and Speciation
Although it is well established that paramagnetic NMR spectroscopy is a powerful tool to derive structural information, the methodology is still not yet universally applied to paramagnetic small molecule complexes. In this paper paramagnetic H NMR spectroscopy is investigated as a convenient method for the experimental inorganic chemist to elucidate solution structures and speciation of small m...
متن کاملIRMPD spectroscopy of metal-ion/tryptophan complexes.
Infrared multiple-photon dissociation (IRMPD) spectroscopy is employed to obtain detailed binding information on singly charged silver and alkali metal-ion/tryptophan complexes in the gas phase. For these complexes the presence of the salt bridge (i.e. zwitterionic) tautomer can be virtually excluded, except for perhaps a few percent in the case of Li+. Two low-energy structures having the char...
متن کاملSome uses of transition metal complexes as anti-cancer and anti-HIV agents.
The success of the clinical uses of cisplatin, cis-[Pt(II)(NH(3))(2)Cl(2)], has stimulated considerable interest in using other metal complexes as new therapeutic agents. This perspective describes our recent work on several classes of gold(III), platinum(II), ruthenium(II, III, IV), iron(II) and vanadium(IV) complexes for anti-cancer and anti-HIV treatments.
متن کاملAnalysis of Bioactive Olygosaccharide-Metal Complexes by Modern FTIR Spectroscopy: Copper Complexes
Spectroscopy of biomolecules has been founded at the end of last century by the researchers working in the field of optical spectroscopy applied to biosystems. Since this time, the interest of the activity has considerably grown up. Researchers have typically used traditional spectroscopic techniques, such as Raman scattering, IR absorption, UV/Vis absorption, circular dichroism, fluorescence, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Discovery Today: Technologies
سال: 2015
ISSN: 1740-6749
DOI: 10.1016/j.ddtec.2015.08.002